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Xeomin Dosing Chart
Date: 16 Dec 2025
Authors: Olivia Drake
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In aesthetic medicine, the correct dosing for the treatment is crucial for achieving positive outcomes, especially with products such as Xeomin and other botulinum toxin injections. If not enough solution is administered, patients would see no difference; if you use too much product, it may create a ‘frozen’ expression on one’s face. So, how should we all work with botulinum toxins such as Xeomin?

Today, we’ll dive deeper into the topic of Xeomin botulinum toxin treatments and their dosing to achieve balanced efficacy and natural-looking results. As a practitioner, you must understand all the delicate nuances of Xeomin dosing and the way it can impact the overall success of the procedure. Let’s start the discussion!

Xeomin Dosing Essentials

Xeomin is the injection brand by Merz Pharmaceutical. It contains botulinum toxin type A, which makes it a muscle relaxant and allows its use for multiple medical and cosmetic purposes. This neurotoxin is administered directly into the muscle to block nerve signals to the muscle, helping it relax. In aesthetic treatments, the product is typically used to deal with dynamic lines, mainly glabellar lines, crow’s feet, and forehead wrinkles.

When discussing patient safety, calculating the correct dose for the treatment is crucial. Specialists must consider whether a person is a treatment-naïve patient or has been previously treated with botulinum toxins, the severity of their condition, the peculiarities of their health situation, and other essential factors. The same goes for the safe and effective treatment of certain medical conditions.

Indication / Area Muscle Units per Side Total Units Notes
Glabellar Lines Corrugator + Procerus 20 U Standard FDA-approved dose
Forehead Lines Frontalis 5–10 U 10–20 U Avoid brow ptosis
Crow’s Feet Orbicularis Oculi 6–12 U 12–24 U Even distribution recommended
Bunny Lines Nasalis 2–5 U 4–10 U Superficial injection
Masseter (Bruxism) Masseter 15–25 U 30–50 U Dose varies by muscle size
Platysmal Bands Platysma 10–20 U 20–40 U Multiple injection points
Hyperhidrosis (Axillary) Sweat Glands 50 U per axilla Intradermal injections

Treatment Areas and Recommended Doses

When calculating the treatment dose, it is important to remember that specialists use reconstituted Xeomin during the session, so its strength varies depending on the product’s concentration. The best way to get a well-made reconstituted solution is to use a preservative-free 0.9% sodium chloride saline. Afterward, the number of recommended units is calculated according to the patient’s needs.

Upper Facial lines (Forehead Lines)

Horizontal lines are among the main aesthetic concerns when it comes to rejuvenating treatments. The initial dosing for forehead Xeomin is between 20 and 40 units. Sometimes, specialists start with a lower dose for those who have never tried the brand and increase the strength of the solution for patients previously treated with Xeomin. Avoiding overdosing is crucial to avoid droopiness and ‘frozen’ facial expression (even though it’s rare, the risks are still there).

Glabellar Lines

Glabellar lines, also known as vertical lines, are situated between the eyebrows. The recommended initial dose is 20 units, divided into 5 injections of 4 units each. Precise placement guarantees a natural look that stays for at least 4 months; however, timely-scheduled maintenance treatment can always save the situation.

Crow’s Feet

The crow’s feet are the small wrinkles in the outer eye corners that occur when we smile, squint, or are generally overly expressive (that’s why these wrinkles are also called ‘dynamic lines’). The right dose for each patient varies, but typically Xeomin repeat treatments for the periorbital area require from 5 to 20 units of the product.

Other Areas

Dosing for other areas, such as neck bands, may differ significantly from the maximum recommended dose for more traditional zones, such as glabellar lines and crow’s feet. The numbers vary based on personal circumstances, such as health conditions, skin concerns, age, and others. That’s why a consultation before the administration is essential to create a proper treatment plan that meets patients’ needs.

Medical Dosing Recommendations (Cervical Dystonia, Upper Limb Spasticity, etc.)

According to clinical studies, the Xeomin dose for medical conditions ranges from 50 units and is recalculated based on the condition being treated. It’s completely natural, considering the difference in the area sizes and severity of the issues — you can’t use the same amount of Xeomin for excessive sweating and complications caused by upper-limb spasticity. That’s why we would like to remind you one more time how important it is to buy Xeomin online from reliable suppliers, as well as choose only licensed Xeomin injectors.

Vial Preparation: Disinfection, Saline Injection, Etc.

Xeomin reconstitution is an important step in the preparation of treatment. Here are the essential steps a specialist must follow to get the injection ready:

  1. Prepare the Xeomin vial. The exposed part of the rubber stopper must be properly cleaned; the most effective option is 70% alcohol. It has to be done before the needle is inserted;
  2. Use a saline injection. The needle must be inserted vertically into the rubber stopper. There, the saline will be drawn into the vial by the vacuum. The remaining saline should be gently infused into the vial to prevent foam formation. If the vacuum refuses to pull Xeomin, ensure to discard it;
  3. Mixing. Xeomin should be mixed with the saline once the syringe is removed. It can be done by swirling and flipping the vial. However, avoid vigorous shaking of the vial.

Ready Xeomin is a clear, colorless solution free of particulate matter.

Safety Information: Adverse Reactions and Limitations

Specialists must discuss safety information with their patients before the treatment to ensure a safe experience in the doctor’s office. Here are the nuances you should highlight:

  1. Contraindications. Xeomin is not recommended for individuals with a known hypersensitivity to the product’s active ingredients. It’s also worth rescheduling the procedure if the treatment area is irritated or hurt. If there are any special cases (pregnancy, chronic illnesses, etc.), a consultation with a doctor is required to ensure Xeomin is a safe option for a patient;
  2. Side effects. Xeomin is generally safe, but sometimes patients may experience mild adverse reactions after the injection. The most common ones are topical, such as redness, swelling, and slight bruising. Increased skin sensitivity may also occur, but it usually goes away within a few days. A doctor must be informed if any signs of allergic reaction or painful sensation occur.
FAQ
  • What Is a Dose Chart for Xeomin?

    Xeomin dose chart is a special table or map with all the facial areas indicated on it. It shows how much Xeomin must be administered in each region to achieve the best results. However, the numbers vary from patient to patient, so the final word must be given by a doctor after examining the area.

  • How Is the Correct Dose for Aesthetic Procedures Decided?

    A doctor must examine the affected area, listen to patients’ concerns and requests, and then decide the optimal way to achieve their goals. In some cases, Xeomin dose is adjusted after some time and may even be used together with other products to achieve better results.

  • Does Everyone Get the Same Dose for the Treatment?

    No, every person is unique, so they require a well-planned treatment to meet their needs. A recommended dosing range for each customer is calculated by a medical professional during the consultation.

  • Can the Dose Chart Change Over Time?

    Yes, the total Xeomin dosage may be adjusted based on individual needs. For example, previously treated patients may need less product due to slower muscle activity resulting from prior Xeomin injections. On the other hand, pediatric patients may need lower doses that are increased gradually as the treatment progresses.

  • Is Xeomin by Merz Pharmaceuticals Safe?

    Yes, Xeomin treatments are 100% safe when performed by educated specialists who understand the product’s working principles, proper administration techniques, and other essentials for a successful session. When performed properly, Xeomin therapy can benefit adult patients greatly in the doctor’s office.

Information Sources:
  • Merz Pharmaceuticals. (2022). Xeomin (incobotulinumtoxinA): Prescribing information. Raleigh, NC: Merz North America, Inc.
  • Dressler, D., & Benecke, R. (2007). Pharmacology of therapeutic botulinum toxin preparations. Disability and Rehabilitation, 29(23), 1761-1768.
  • Flynn, T. C. (2010). Botulinum toxin: Examining duration of effect in facial aesthetic applications. American Journal of Clinical Dermatology, 11(3), 183-199.
  • Pickett, A. (2009). Dysport: Pharmacological properties and factors that influence toxin action. Toxicon, 54(5), 683-689.
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