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Aesthetic medicine offers a great selection of injectable skin treatments, including hyaluronic acid, calcium-hydroxylapatite, and other dermal fillers. Due to its advanced composition and properties, Nucleofill treatment definitely stands out. Below, you will find a detailed overview of it!

General Information on Nucleofill

Nucleofill is a polynucleotide-based injectable treatment with an antioxidant effect that is derived from salmon DNA. It belongs to the class of anti-aging treatments. It is primarily used to boost collagen production and enhance the quality of the skin.

Naturally derived polynucleotides with a highly purified polynucleotide matrix ensure skin tissues with profound hydration and create a visible rejuvenation effect. They have shown significant effectiveness in aesthetic medicine.

Nucleofill’s product line includes several aesthetic solutions, namely:

Each product in the Nucleofill range has its own properties and indications. At the same time, however, they all are characterized by high-quality composition, strong effectiveness, and long-lasting duration of their action.
The manufacturer of Nucleofill treatment solutions is Promoitalia Laboratories. It is an Italian pharmaceutical company specializing in producing innovative treatment solutions specifically created to fulfill a wide range of aesthetic goals.

Working Principle

The working principle of Nucleofill is exceptionally advanced. After being injected into the human body, biological molecules in the composition of the treatment signal cells to perform certain actions, such as the acceleration of collagen production.

In other words, Nucleofill treatments employ a scientifically proven method of rejuvenating all skin types by improving their overall quality. By means of restructuring the dermal matrix via new collagen molecules, they nurture the skin from within and grant a patient a youthful appearance.
Nucleofill has the power to accelerate the regeneration of both deep tissues (like adipose and bone tissue) and superficial tissues of the skin. It even has the power to ensure the deep hydration of the subcutaneous tissue of the skin. In general, Nucleofill is effective for all three types of cutaneous membrane tissues.


Nucleofill is a new bio-restructuring gel composed of polynucleotides. It is primarily indicated to improve the overall condition of the flabby and dehydrated skin by means of:

  • Improving skin elasticity and skin hydration;
  • Reducing fine lines and wrinkles (especially superficial wrinkles);
  • Creating a non-surgical eye lift;
  • Minimizing dark circles and lower eyelid puffiness (thus, Nucleofill functions as an alternative to a tear trough filler based on hyaluronic acid);
  • Enhancing skin firmness and skin tension by tightening loose skin tissues;
  • And so on.

In other words, the treatment ensures deep skin renewal. Its deep moisturizing effect helps to activate processes of bio-regeneration of the skin tissues (regardless of a patient’s skin type).

Apart from the aforementioned indications, Nucleofill might also be used to fight female pattern hair loss improving the poor circulation of blood around the hair follicle. By increasing circulation of blood around the treatment area, Nucleofill Hair profoundly boosts new hair growth.


Due to its natural origin and high-quality composition, Nucleofill belongs to exceptionally safe skin boosters. However, it should not be injected if a patient has any of the following contraindications to the treatment:

  • Pregnancy or lactation;
  • Serious diseases (such as oncology, epilepsy, poor blood clotting, and so on);
  • Tendency to keloid formation;
  • Ongoing skin inflammation or damage around the injection site;
  • Intake of incompatible medications;
  • And so on.

Ignorance of these contraindications when undergoing the Nucleofill injection might lead to deep discomfort and other unwanted complications (including skin tissue atrophy). Thus, it is of vital importance to take them into account.

All Nucleofill products (regardless of whether they have a medium molecular weight structure or low molecular weight structure) belong to anti-ageing treatments intended for professional use. Only a certified healthcare provider is eligible to administer them into a patient’s skin cells.

Expected Results

In most cases, one might notice a visibly rejuvenated skin immediately after undergoing an injection of Nucleofill. Through the activation of membrane receptors in the skin, the product substantially improves the overall appearance of a patient.

On average, the duration of Nucleofill equals six months. Still, it strongly depends on the individual peculiarities of each patient (including their health condition or age) and the after-treatment care a patient undergoes (for instance, it is preferable to avoid direct sun exposure to prolong the results of Nucleofill).

Buy Nucleofill Online on FillerCloud!

If you are currently looking for a beneficial store to buy hyaluronic acid fillers, calcium hydroxyapatite fillers, or polynucleotide fillers (including Nucleofill), check out what FillerCloud offers. Here, you will find a wide selection of original aesthetic products, wholesale discounts, and reliable delivery options.

So, order Nucleofill online and provide your patients with profound skin tissue hydration in a safe and effective way!

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